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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Sildenafil:
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ACUTE EXPOSURE INFORMATION
- USES: Smooth muscle relaxant used for erectile dysfunction and pulmonary hypertension. Sildenafil is also abused, often in conjunction with other drugs to enhance sexual performance.
- PHARMACOLOGY: Inhibition of cGMP specific phosphodiesterase type-5 (PDE5) in smooth muscle in the pulmonary vascular bed in the lungs and the corpus cavernosum of the penis.
- TOXICOLOGY: Overdose causes excessive vasodilatation resulting in hypotension, tachycardia, headache, priapism, facial flushing, dizziness, and general weakness.
- EPIDEMIOLOGY: Poisoning is uncommon and rarely severe.
- WITH THERAPEUTIC USE
- ADVERSE EFFECTS: Facial flushing, rash, diarrhea, dyspepsia, dizziness/vertigo, headache, abnormal vision, nasal congestion, hypotension, tachycardia, myocardial infarction, non-arteritic ischemic optic neuropathy, priapism (rare), and musculoskeletal pain have been reported.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE POISONING: Headache facial flushing, dizziness, general weakness, priapism and vertigo.
- SEVERE POISONING: Severe effects may include significant hypotension, tachycardia, and generalized weakness. Theoretically, CNS depression, cerebral ischemia, and other end organ ischemia are possible after severe overdose, but have not been reported.
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