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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Pregabalin:
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ACUTE EXPOSURE INFORMATION
- USES: Pregabalin is indicated for the treatment of diabetic or postherpetic neuralgia, fibromyalgia, and partial seizures.
- PHARMACOLOGY: The mechanism of action in humans is unknown; however, pregabalin possibly modulates calcium channel function by reducing the calcium-dependent release of several neurotransmitters in vitro and binds with high affinity to the alpha(2)-delta site in central nervous system tissues, which may lead to antiseizure and antinociceptive effects.
- EPIDEMIOLOGY: Overdose is rare.
- WITH THERAPEUTIC USE
- ADVERSE EFFECTS: COMMON: dizziness and somnolence, ataxia, tremor, amnesia, speech disturbances, myoclonus, neuropathy, confusion, euphoria, incoordination, abnormal gait, nervousness, twitching, headache. LESS COMMON: peripheral edema, a mildly prolonged PR interval, decreased platelet count, and increased creatine kinase, rhabdomyolysis and blurred vision.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Overdose data are limited. During clinical trials, the highest reported accidental overdose of pregabalin was 8000 mg; no notable consequences were observed. During clinical studies, some patients took as much as 2400 mg/day. Adverse events in patients exposed to doses greater than or equal to 900 mg were not clinically different from those of patients who received recommended doses of pregabalin.
- SEVERE TOXICITY: An adult intentionally ingested 8.4 g of pregabalin and developed CNS depression and coma approximately 3 hours after exposure. The patient required intubation and mechanical ventilation for 26 hours. No permanent sequelae occurred.
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