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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Bortezomib:
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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Adverse effects reported with bortezomib therapy have included gastrointestinal effects (nausea (57%), vomiting (35%), diarrhea (57%), decreased appetite (34%), abdominal pain (16%), and constipation (42%)), fever (35%), thrombocytopenia (35%), neutropenia (19%), anemia (26%), asthenia (fatigue, malaise, weakness) (61%), peripheral neuropathy (36%) and hypotension (13%). In postmarketing experience, complete atrioventricular block, cardiac tamponade, ischemic colitis, encephalopathy, dysautonomia, bilateral deafness, DIC, hepatitis, acute pancreatitis, and toxic epidermal necrolysis have occurred.
- Other adverse effects included rash, hyponatremia, hypokalemia, paralytic ileus, hyperbilirubinemia, increases in liver enzymes, hepatitis, bone pain, myalgia, rhabdomyolysis, leukoencephalopathy, headache, dizziness, paresthesia and dysesthesia, psychiatric disorders, cough, dyspnea, nasopharyngitis, fever, rigor, and tumor lysis syndrome.
- WITH POISONING/EXPOSURE
- OVERDOSE: Limited data. Twice the recommended dose has resulted in an acute onset of hypotension and thrombocytopenia resulting in fatal outcomes.
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