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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for 7553-56-2:
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ACUTE EXPOSURE INFORMATION
- WITH POISONING/EXPOSURE
- INGESTION - The CNS, cardiovascular and renal toxicity following acute iodine ingestion appear to be due to the corrosive gastroenteritis and resultant shock. Vomiting, delirium, headache, hypotension, and circulatory collapse may be noted following severe intoxication. In addition, a metallic taste may be noted following acute ingestion. Seizures occurred in one case.
- Death is rare following acute iodine ingestion. It is estimated that the mean lethal dose in an adult lies between 2 to 4 grams of free iodine or 1 to 2 ounces of strong iodine tincture (7 percent iodine and 5 percent potassium iodide in 83 percent alcohol).
- The presence of food in the stomach inactivates iodine by converting it to iodide which is relatively innocuous. A blue colored emesis indicates the presence of food (starch) in the stomach and the conversion of iodine to iodide.
- INHALATION - The warning properties of iodine vapor may not prevent excessive inhalation and resultant respiratory distress. Inhalation of iodine vapors is very irritating to the mucous membranes.
- OCULAR EXPOSURE - may result in severe burns and blepharitis.
- DERMAL EXPOSURE - Povidone-iodine has been demonstrated to be an effective surgical antiseptic used either as a powder or irrigating solution (0.5 to 10 percent). However, due to iodine absorption from irrigation sites, certain precautions are recommended when povidone-iodine is used in an irrigation solution. Seizure activity was reported in one adult following mediastinal irrigation, and acute renal failure was reported in another adult following the same therapy.
- Dermal application of strong iodine solutions may lead to local inflammatory reactions. Using copious amounts of iodine-containing compounds to irrigate wounds or burns has precipitated serious or fatal reactions.
- Delirium, nausea, vomiting and taste disturbances have been reported from chronic use of iodoform gauze.
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