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ACUTE EXPOSURE INFORMATION

  1. Vinyl acetate is moderately toxic by the ingestion, inhalation, and intraperitoneal routes of exposure. It is irritating to the eyes, skin, mucous membranes, and respiratory tract. Prolonged dermal contact (clothing wet with vinyl acetate) may result in severe irritation or blistering of the skin.
  1. In a study of 21 workers exposed for an average of 15 years at concentrations between 5 and 10 ppm (with occasional excursions above 300 ppm), it produced no serious chronic effects.
    1. Chronic occupational exposure has been reported to cause CNS symptoms, chronic bronchitis, cardiovascular symptoms, liver function changes, and hepatic enzyme induction.
  1. Vinyl acetate is a questionable carcinogen with experimental carcinogenic and tumorigenic data. It causes experimental reproductive effects. Human mutation data have been reported.
  1. Populations at special risk include those with chronic irritation of the respiratory tract, chronic inflammatory conditions of the skin, and those with chronic eye irritation.
  1. Routes of human exposure primarily include occupational exposure via inhalation of the vapor and contact of the liquid or vapor with the skin and eyes.
  1. The general population may be exposed through inhalation of contaminated air in the vicinity of its commercial production and use and in the vicinity of waste disposal sites containing the compound. Dermal contact from residual monomer remaining in polyvinyl acetate products may be possible.
    1. Although never demonstrated experimentally, residual monomer (in polyvinyl acetate containers used to store food products) may leach into food products and result in ingestion. Vinyl acetate exhibits relatively low toxicity as a monomer, and more toxicity as a polymer. Primary human exposure, however, most likely results through inhalation at occupational sites.
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