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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Propylthiouracil:
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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- ADVERSE EFFECTS: Chronic therapeutic ingestion can result in a variety of immunologic-mediated adverse effects which are not expected to occur in overdose, including leukopenia, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, thrombocytopenia, vasculitis and hypoprothrombinemia. In addition, chronic ingestion of propylthiouracil have produced a characteristic hepatocellular or mixed cytotoxic-cholestatic hepatitis, believed to be a hypersensitivity reaction. Transaminase levels are typically elevated, with or without elevated bilirubin and alkaline phosphatase. The onset of symptoms is 2 weeks to 5 months after initiation of therapy. Rare reports of hepatitis, hepatic necrosis, encephalopathy have occurred; some cases have been fatal. Skin rashes may occur secondary to hematologic toxicity during chronic therapy. Cutaneous hypersensitivity vasculitis is an immune-mediated adverse reaction to propylthiouracil. Arthritis as well as polymyositis, synovitis, arthralgias, and an SLE-like syndrome, exertional dyspnea, hypoxemia, cough, and productive sputum may be observed with therapeutic use. Hypocalcemia, eosinophilia, nephritis have also been reported with therapeutic use.
- WITH POISONING/EXPOSURE
- OVERDOSE: Very little data are available on the effects of acute overdose. Decreased T3 and elevated alkaline phosphatase levels were the only effects seen after a massive overdose in a 12-year-old girl.
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