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ACUTE EXPOSURE INFORMATION

  1. USES: Nitazoxanide oral suspension is used to treat diarrhea caused by Cryptosporidium parvum and Giardia lamblia in pediatric patients 1 to 11 years of age. Nitazoxanide oral tablets are used for the same indications in patients 12 years of age and older.
  1. PHARMACOLOGY: Nitazoxanide is an antiparasitic agent (nitrothiazole derivative) with antiprotozoal activity that appears to interfere with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction required for anaerobic energy metabolism.
  1. EPIDEMIOLOGY: Overdose is rare.
  1. WITH THERAPEUTIC USE
    1. COMMON: The most common adverse effects include abdominal pain, diarrhea, headache, nausea, vomiting.
    1. LESS FREQUENT: Although causality has not been established, other adverse effects that have been reported less frequently (less than 1%) include dizziness, somnolence, insomnia, tremor, hypesthesia, dyspepsia, anorexia, flatulence, constipation, dry mouth, thirst, discolored urine, dysuria, amenorrhea, menorrhagia, renal pain, labial edema, elevated SGPT, elevated creatinine (oral suspension), anemia, leukocytosis, rash, pruritus, eye discoloration, ear ache, epistaxis, lung disease, pharyngitis, tachycardia, syncope, hypertension, myalgia, leg cramps.
  1. WITH POISONING/EXPOSURE
    1. Specific overdose information is not available; however, single oral doses up to 4000 mg have been tolerated.
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