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|Example of Acute Exposure data from MEDITEXT.|
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• Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (1R,2S)-rel-
• Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (Z)-, monohydrochloride
• Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, cis-(+-)-
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Example Content from MEDITEXT for Milnacipran:
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ACUTE EXPOSURE INFORMATION
- USES: Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used in the management of fibromyalgia.
- PHARMACOLOGY: Inhibits neuronal norepinephrine and serotonin reuptake; thus potentiating the serotonergic and noradrenergic activity in the CNS.
- TOXICOLOGY: Primarily sympathomimetic activity, potential for serotonin syndrome.
- EPIDEMIOLOGY: Several deliberate poisonings have been reported in postmarketing experience. Fatalities are rare.
- WITH THERAPEUTIC USE
- COMMON: Headache, nausea and vomiting, constipation, hypertension, tachycardia and palpitations. Elevated liver enzymes have been reported.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Somnolence, nausea and vomiting are common. Tachycardia and hypertension have been reported.
- SEVERE TOXICITY: Milnacipran may cause seizures and serotonin syndrome. Acute stress cardiomyopathy developed in a woman after ingesting 3000 mg of milnacipran.
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