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Example Content from MEDITEXT for Indomethacin:
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ACUTE EXPOSURE INFORMATION
- USES: Used as an analgesic, antipyretic, and antiinflammatory drug to treat a wide range of pain and inflammatory conditions such as gout, pericarditis, several arthritis conditions, and dysmenorrhea. It is used in neonates for treatment of patent ductus arteriosus.
- PHARMACOLOGY: Inhibits cyclooxygenases, COX1 and COX2. This results in the decreased synthesis of prostaglandins, thromboxane A2, and decreased pain and inflammation.
- TOXICOLOGY: GI: Indomethacin is a direct GI irritant, and the inhibition of prostaglandin synthesis interferes with the maintenance of the GI barrier. Inhibition of thromboxane A2 in platelets prolongs bleeding time and predisposes to GI bleeding. RENAL: Decreases in prostaglandins I2 and E2, which have vasodilatory and natriuretic effects in the kidney that can lead to salt and water retention, and renal failure.
- WITH THERAPEUTIC USE
- COMMON: Nausea, vomiting, gastritis, GI ulceration with perforation and hemorrhage, frontal headache, LESS COMMON: Dizziness, vertigo, stupor, hypersensitivity reactions, renal insufficiency, neutropenia, thrombocytopenia, and aplastic anemia.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Nausea, vomiting, and mild abdominal pain may develop.
- SEVERE TOXICITY: CNS disorientation, mental confusion, and lethargy have been reported. Upper GI bleeding and acute renal failure are also possible.
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