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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Hexane:
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ACUTE EXPOSURE INFORMATION
- USES: Industrial solvent used as a component of glues, silicones, spray paints, specialized cements, and break cleaners.
- TOXICOLOGY: Hexanes, especially, n-hexane, are metabolized to a 2,5-hexanedione intermediate that decreases the phosphorylation of neurofilament proteins and there disrupts the axonal cytoskeleton.
- EPIDEMIOLOGY: Toxicology and poisoning from exposure to hexanes is uncommon.
- WITH POISONING/EXPOSURE
- DERMAL: Hexane is irritating to skin, and can cause redness, pain and blister formation. Chronic exposure can cause defatting dermatitis.
- INGESTION: Not well described. Can cause gastrointestinal irritation, aspiration pneumonitis, and likely CNS depression.
- OCULAR: Hexane is an eye irritant. Splash contact might cause corneal injury.
- INHALATION: Is the most common route of exposure. Low concentrations cause eye and respiratory irritation, dizziness, headache, nausea, and vomiting. High concentrations can also cause CNS depression. At very high concentrations, hexane can cause death from asphyxiation as it displaces oxygen. Chronic inhalation can cause a peripheral neuropathy characterized by pain, weakness, loss of sensation, impaired gait, myalgias, muscle atrophy, hyporeflexia, and sometimes visual disturbances.
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