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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Ethylene glycol methyl ether:
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ACUTE EXPOSURE INFORMATION
- USES: Ethylene glycol monomethyl ether (EGME) is used as a solvent in the chemical synthesis of a variety of products and is widely used in manufacturing. It is also found in surface coats such as quick-drying varnishes, nail polishes, and wood stains and paints.
- TOXICOLOGY: In overdose, EGME causes central nervous system, renal, and hematologic toxicity. It remains speculation that glycol ethers may undergo cleavage of the ether bond to produce ethylene glycol with subsequent metabolism to oxalate.
- EPIDEMIOLOGY: Clinically significant exposure to EGME is uncommon. Severe toxicity is rare. Deaths have been reported.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Eye and mucous membrane irritation may occur with inhalation exposure. Dermal irritation may occur with skin exposure. Headache, drowsiness, lethargy, fatigue, dizziness, and mild anemia or granulocytopenia may develop with relatively low level inhalation exposures.
- SEVERE TOXICITY: ACUTE: Higher concentration inhalation exposures may cause ataxia, tremor, confusion, dysarthria, personality changes, and coma that generally and gradually resolve with cessation of exposure. Acute ingestions may cause agitation, confusion, CNS depression, coma (may be delayed with onset of 8 to 18 hours), metabolic acidosis, acute renal failure, proteinuria, hematuria, oxaluria, and hemorrhagic gastritis.
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