RightAnswer Knowledge Solutions provides access to hundreds of data sources. Our premier and proprietary sources include fully-researched documents from well-established experts in the chemical and HazMat fields.
A search in our system for this chemical would return results – all in one place -- in the following categories from the listed data sources.
- Chemical Identification
- Environmental Hazards
- First Aid/Medical Treatment
- Handling/Storage/Shipping/Waste Management
- MSDS Documents
- Personal Protection
- Physical Hazards/Corrective Response Actions
- Physical/Chemical Properties
- Report Abstracts and Studies
- Reproductive Risk
- Toxicology/Health Hazards/Exposure
|Example of Acute Exposure data from MEDITEXT.|
Other Government Links Searched via RegsKnowledge:
State Environmental Regulations
Example Content from MEDITEXT for Diethylene glycol:
Please note: this is an extract of information from a larger document. Full document and details are available by subscription.
ACUTE EXPOSURE INFORMATION
- USES: Diethylene glycol is an industrial solvent and intermediate in the polymers and higher glycols. It can also be found in radiator fluid, antifreeze, brake fluid, Sterno, wall stripper, and in cleaning solutions.
- TOXICOLOGY: Diethylene glycol is metabolized to 2-hydroxyethoxyacetaldehyde by alcohol dehydrogenase oxidation, then to 2-hydroxyacetic acid (HEAA) by aldehyde dehydrogenase. HEAA causes acidosis, renal failure, and neurologic dysfunction. It is thought that the parent compound is toxic as well. Therefore, despite alcohol dehydrogenase blockade, patients may go on to develop signs of end organ toxicity.
- EPIDEMIOLOGY: Inadvertent exposures to low concentration products are relatively common but generally do not result in significant toxicity. Large, deliberate acute ingestions may cause life-threatening toxicity. Most fatalities have involved epidemics where people (primarily children) were repeatedly exposed due to contaminated medication in developing countries with weak manufacturing controls and limited access to intensive medical care.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Common initial symptoms are heartburn, followed by nausea and abdominal cramps, vomiting and occasionally diarrhea. Headaches are also reported.
- SEVERE TOXICITY: Inebriation and metabolic acidosis may develop early. Later symptoms include back pain and severe abdominal pain; pancreatitis has also been reported after poisoning. Polyuria develops, followed by oliguria, anuria, and renal failure. Hepatotoxicity may develop. CNS depression, obtundation, or coma are common late in the course of toxicity, generally 3 to 5 days after exposure. Metabolism produces an acidosis caused by a toxic metabolite of the parent compound. CNS and respiratory depression, coma, respiratory arrest, and pulmonary edema have preceded death in reported cases. Tremors and rare seizures may accompany uremia. Peripheral and/or cranial neuropathies with bulbar palsy may develop weeks after severe poisoning.
© 2011-2017 RightAnswer.com, Inc. and/or its licensors. All rights reserved. No claim to original U.S. Govt. works.