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ACUTE EXPOSURE INFORMATION

  1. Human poisoning by norbormide is unlikely due to specificity for rats. Doses of 20 to 300 mg have been given to human volunteers with only minimal hypotensive effects. A dose of 300 mg corresponds to 60 grams of the 0.5% bait and 30 grams of the 1% bait.
  1. RATS given norbormide first present with a hunched position, followed by development of locomotor difficulties and weakness, but not paralysis of the hindlegs. Struggling, dyspnea, and mild seizures precede death which occurs within 15 minutes to 4 hours as a result of intense vasoconstriction.
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