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ACUTE EXPOSURE INFORMATION
- Human experience with dimethyl-p-phenylenediamine (DMPD) is limited. DMPD may be toxic by inhalation of the vapor or by the oral, dermal, subcutaneous, intraperitoneal or intravenous routes.
- DMPD is a skin and eye irritant and sensitizer. Highly concentrated solutions may produce vesication. Life threatening toxicity may result from adult skin exposure to very minute quantities (1 teaspoon), based on animal studies. This has not been confirmed in humans. Ingestions have not been reported, but esophageal or gastric irritation might be predicted based on this agent's other irritant properties.
- DMPD is a weak inducer of methemoglobinemia in rats. It has produced hyperglycemia, hyperexcitability, dyspnea, seizures and death in animals.
- Paraphenylenediamine, a closely related compound and metabolite of DMPD, has caused severe eye reactions including hypersensitivity, optic neuritis, protrusion and possibly lenticular opacities in humans.
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