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ACUTE EXPOSURE INFORMATION

  1. USES: An antimalarial agent, effective as a tissue schizonticide, indicated for the radical cure (prevention of relapse) of vivax malaria.
  1. PHARMACOLOGY: Primaquine is an 8-aminoquinoline compound that eliminates exoerythrocytic (tissue) infection, thereby preventing the development of the erythrocytic forms of the parasite responsible for relapses in vivax malaria.
  1. TOXICOLOGY: Primaquine is an oxidizing agent that can cause methemoglobinemia or hemolytic anemia, especially in susceptible populations.
  1. EPIDEMIOLOGY: Primaquine overdose is rare in the United States, but may be common in areas where malaria is endemic.
  1. WITH THERAPEUTIC USE
    1. COMMON: Nausea, vomiting, and abdominal cramps are frequently reported with primaquine therapy.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Nausea, abdominal pain, and headaches have occurred at doses of 60 to 240 mg/day.
    1. SEVERE TOXICITY: Hematologic effects, including methemoglobinemia, hemolytic anemia, leukopenia, and granulocytopenia, have been reported following high doses of primaquine.
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