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ACUTE EXPOSURE INFORMATION
- Bromoform is toxic by ingestion, inhalation, and skin absorption. It is a central nervous system depressant. Accidental ingestion of the liquid has produced central nervous system depression with coma and loss of reflexes. With very large doses, death may occur and is usually due to respiratory failure. Smaller doses have led to listlessness, headache, and vertigo. The major route of human exposure is from drinking water.
- Inhalation may cause irritation of the respiratory tract, pharynx, and larynx, producing salivation. Inhalation may be fatal as a result of spasm, inflammation, and edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
- It has anesthetic properties similar to those of chloroform, but is not sufficiently volatile for inhalation purposes and is too toxic for human use.
- Exposure to vapors or dust may cause burning of the eyes and lacrimation.
- Bromoform is a skin and eye irritant. Repeated or prolonged contact may cause dermatitis.
- Chronic effects have not been reported from industrial exposure, but have been reported following oral abuse.
- In animal studies, target organs of toxicity are the skin, liver, kidneys, respiratory system, lungs and central nervous system.
- Chronic oral abuse of bromoform may result in bromism.
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