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Example Content from MEDITEXT for 75-01-4:


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ACUTE EXPOSURE INFORMATION

  1. GENERAL - In acute exposure, deaths are most often due to CNS and respiratory depression. The primary toxic hazard is exposure to vinyl chloride monomer (VCM) gas rather than to poly vinyl chloride (PVC) products (except during pyrolysis). There may be a long latent period between exposure and symptom onset.
  1. ACUTE - The nervous system is the primary target of acute vinyl chloride exposure. Signs and symptoms following ingestion include weakness; ataxia; inebriation; headache; fatigue; numbness; tingling and pallor or cyanosis of the extremities; nausea; abdominal pain; GI bleeding; visual disturbances; cardiac dysrhythmias; narcosis and death. Vinyl chloride is a severe irritant of the eyes, skin, and mucous membranes.
  1. CHRONIC - Enhanced collagen deposition and thickening of the subepidermal layer of the skin, Raynaud's phenomenon, hepatomegaly, hepatic fibrosis, splenomegaly, thrombocytopenia, sensory-motor polyneuropathy, trigeminal sensory neuropathy, minor pyramidal signs, cerebellar and extrapyramidal motor disorders, degenerative bone changes, and acro-osteolysis may occur with chronic exposure to vinyl chloride. Vinyl chloride is a known human carcinogen and has caused angiosarcoma of the liver in heavily exposed workers.
  1. DERMAL - Direct contact with liquid vinyl chloride or escaping gas can cause frostbite injury.
  1. INHALATION - Inhalation may cause CNS and respiratory depression and seizures.
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