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ACUTE EXPOSURE INFORMATION

  1. WITH THERAPEUTIC USE
    1. Moderate to severe sedation is the most common adverse effect with metyrosine therapy. Onset occurs within 24 hours of beginning metyrosine therapy with maximal effects occurring after 2 to 3 days of therapy, and then tapering off as therapy is continued. Sedation or fatigue may persist with metyrosine doses of greater than 2000 mg/day.
    1. Other adverse effects that appear to be dose-dependent include extrapyramidal signs (drooling, tremor, and speech difficulty), anxiety, agitation, hallucinations, confusion, diarrhea, and dry mouth. Crystalluria, transient dysuria and hematuria, and hypersensitivity reactions have been reported rarely.
  1. WITH POISONING/EXPOSURE
    1. Overdose information is limited. It is anticipated that overdose effects would be an extension of adverse effects occurring during therapeutic use, including sedation, extrapyramidal effects, anxiety, agitation, hallucinations, crystalluria, dysuria and hematuria.
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