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ACUTE EXPOSURE INFORMATION

  1. USES: Rifapentine is indicated for the treatment of pulmonary infection caused by Mycobacterium tuberculosis in combination with other antituberculosis agents.
  1. PHARMACOLOGY: Rifapentine is a cyclopentyl rifamycin derivative antibiotic with bactericidal activity against mycobacterium tuberculosis.
  1. EPIDEMIOLOGY: Overdose is uncommon.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: Red-orange discoloration of body tissues and fluids, including skin, teeth, tongue, urine, feces, saliva, sweat and tears, may commonly occur with therapy. Other reported adverse effects or alterations in laboratory studies include: elevated liver enzyme levels, neutropenia, anemia, lymphopenia, proteinuria, hematuria, hypoglycemia, arthralgias and rash.
  1. WITH POISONING/EXPOSURE
    1. OVERDOSE: Information is limited. Administration of 1200 mg as a single oral dose resulted in minor adverse effects including heartburn, headache, and increased urinary frequency.
    1. MILD TO MODERATE TOXICITY: Nausea, vomiting, anorexia, arthralgias, rash and elevated liver enzymes can develop. Red-orange discoloration of the skin, body tissues and fluids may occur.
    1. SEVERE TOXICITY: Hepatotoxicity, hyperbilirubinemia, and hematologic toxicity may develop following a significant exposure.
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