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ACUTE EXPOSURE INFORMATION
- USES: Sulfasalazine is used for treatment of ulcerative colitis, rheumatoid arthritis, and polyarticular-course juvenile rheumatoid arthritis.
- PHARMACOLOGY: The mode of action of sulfasalazine or its metabolites, 5-aminosalicylic acid (mesalamine) and sulfapyridine, is unknown but may be related to anti-inflammatory and immunomodulatory properties of the agent.
- EPIDEMIOLOGY: Overdose is rare.
- WITH THERAPEUTIC USE
- COMMON: Anorexia, headache, nausea, vomiting, abdominal discomfort, dyspepsia, and rash. Other rare adverse effects include pruritus, urticaria, rash, fever, cyanosis, dizziness, malaise, depression, fatigue, insomnia, confusion, stomatitis, elevated liver enzyme levels, hepatic necrosis, granulomatous hepatitis, folic acid deficiency, Heinz body anemia, hemolytic anemia, leukopenia, thrombocytopenia, neutropenia, macrocytosis, megaloblastic anemia, agranulocytosis, methemoglobinemia, aplastic anemia, tachycardia, acute allergic reaction, fixed drug eruption, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, pancreatitis, taste disturbances, renal calculi, nephrotic syndrome, myopathy, pneumonia, and pulmonary infiltrates.
- WITH POISONING/EXPOSURE
- TOXICITY: Overdose effects are anticipated to be an extension of adverse effects observed following therapeutic doses. Nausea, vomiting, abdominal pain and central nervous system symptoms (eg, drowsiness, seizures, headache), methemoglobinemia, and tachycardia have been reported following sulfasalazine overdose.
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