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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- PARENTERAL: Rare reports of anaphylactoid reaction (ie, respiratory distress, pruritus, shock and abdominal pain) have been reported, usually after multiple large parenteral doses of 25 to 100 mg of thiamine for more than 7 days. OTHER events have included injection site pain following intravenous administration. There are very few adverse events reported with parenteral administration. ORAL: Adverse events are not usually reported following oral supplementation, even following high doses of 300 mg/day for several weeks.
- WITH POISONING/EXPOSURE
- OVERDOSE: Single parenteral doses of 100 to 500 mg have been given with no toxic effects reported. ORAL: Toxicity is uncommon following oral supplementation; excessive doses are usually excreted. NOTE: The parenteral formulation contains aluminum that may be potentially toxic to patients at risk (impaired renal function) or following prolonged therapy. See the ALUMINUM management as appropriate.
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