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ACUTE EXPOSURE INFORMATION

  1. Tris(2-chloroethyl)amine is a potent nitrogen mustard compound which has been tested as a military chemical warfare agent. It is an irritant of the eyes, skin, and the respiratory and gastrointestinal tracts. Systemic absorption causes inhibition of cell mitosis, resulting in severe hemorrhagic diarrhea, necrotic lesions of the gastrointestinal mucosa, and bone marrow depression. Convulsions have been noted in exposed experimental animals only.
  1. Eye exposure can cause severe irritation. Concentrations that do not cause skin or respiratory tract irritation can be extremely irritating to the eyes.
  1. Dermal exposure to the liquid or vapor can cause erythema, pruritus, irritation, and delayed blister formation in erythematous areas.
  1. Vapor inhalation can cause severe respiratory tract effects, beginning with irritation of the nose and throat. Cough, hoarseness, fever, difficulty in breathing, moist rales, and bronchial pneumonia may occur.
  1. Ingestion can produce nausea and vomiting. Severe esophageal or gastrointestinal tract irritation may be predicted to occur following ingestion, based on this agent's other irritant properties.
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