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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Myelosuppression is the dose-limiting toxicity of cladribine. Its duration may be prolonged after discontinuation of therapy. Other adverse effects, frequently reported with cladribine therapy, include fever, fatigue, nausea, rash, and headache.
- WITH POISONING/EXPOSURE
- Cladribine overdose information is limited. Severe neurotoxicity (paraparesis/quadriparesis), acute nephrotoxicity, severe myelosuppression, and fatal systemic bacterial or fungal infections have been associated with very high doses.
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