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ACUTE EXPOSURE INFORMATION

  1. Bitoscanate is a tasteless, odorless, colorless, needle-like crystalline solid material prepared from mustard powder acid and used as an anthelmintic against nematodes, especially hookworms (Necator sp.) and Ancylostoma duodenale.
    1. Side effects reported with therapeutic use have been nausea, vomiting, diarrhea, abdominal pain or discomfort, loss of appetite, dizziness or giddiness, vertigo, weakness, headache, and an itching sensation over the body. Such side effects have most often been mild and required no treatment.
      1. No significant changes in blood counts or liver and kidney function tests were noted in clinical trials with therapeutic doses. No adverse effects on the bone marrow, liver, or kidney were seen in children and adolescents administered therapeutic doses.
    1. Bitoscanate can be absorbed by the oral or parenteral routes, and can cause hallucinations and nausea. At the time of this review, no information was available on whether or not bitoscanate can be absorbed by the inhalation or percutaneous routes.
  1. Bitoscanate releases toxic and irritating fumes of cyanide and oxides of nitrogen and sulfur when heated to decomposition.
    1. If CYANIDE poisoning is suspected, REFER to the SODIUM or POTASSIUM CYANIDE documents or the CYANIDE or HYDROGEN CYANIDE managements for more information.
    1. Inhalation of the oxides of nitrogen and sulfur decomposition products would be predicted to result in respiratory tract irritation with bronchospasm, chemical pneumonitis, or noncardiogenic pulmonary edema.
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