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ACUTE EXPOSURE INFORMATION
- In massive overdose, these agents have produced rapid and persistent hypoprothrombinemia and associated bleeding diathesis. Chlorophacinone produces especially prolonged periods of hypocoagulability. Once coagulation defects occur, they may persist for 6 weeks to many months. Because it has an elimination half-life of several days, daily exposures would produce cumulative toxicity. No chronic data were found for chlorophacinone in humans, however.
- Cardiopulmonary injury and neurologic toxicity have been reported with the indandiones in animals but not humans.
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