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ACUTE EXPOSURE INFORMATION

  1. USES: Used for the treatment of epidermal growth factor receptor (EGFR)-expressing, metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.
  1. PHARMACOLOGY: Panitumumab is a recombinant, human IgG2 kappa monoclonal antibody and binds to human EGFR specifically, on both normal and tumor cells. Panitumumab competitively inhibits the binding of ligands for EGFR.
  1. EPIDEMIOLOGY: Overdoses are rare.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: COMMON: Dermatologic effects develop in most (90%) patients, and include: erythema (65%), acneiform dermatitis (57%), pruritus (57%), nail changes (29%), paronychia (25%), exfoliation (25%), skin fissures (20%), and dry skin (10%). Other adverse effects include: hypomagnesemia (38%), fatigue (26%), abdominal pain (25%), nausea/vomiting (23% and 19%), diarrhea (21%), constipation (21%), and cough (14%). Less common adverse effects include: hyperglycemia, hypokalemia, hypocalcemia, cheilitis, ocular toxicities (e.g. conjunctivitis, ocular hyperemia, increased lacrimation, eye/eyelid irritation, and eyelash growth), thrombophlebitis, bone pain, back pain, asthenia, dyspnea, and infectious complications. Rare, but serious complications include pulmonary fibrosis and infusion-related toxicity (e.g. anaphylactoid reactions, bronchospasm, hypotension).
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Skin toxicity, diarrhea, dehydration and fatigue have been reported in patients receiving doses up to approximately twice the recommended therapeutic dose (12 mg/kg).
    1. SEVERE TOXICITY: No severe toxicity were reported following doses of approximately twice the recommended therapeutic dose (12 mg/kg).
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