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Example Content from MEDITEXT for 33089-61-1:
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ACUTE EXPOSURE INFORMATION
- USES: Amitraz is an insecticide used on crops and topically for treatment of parasitic infections of farm animals. It is effective against mites, fleas, and other insects.
- TOXICOLOGY: Amitraz acts as a central alpha-2 adrenergic agonist causing CNS depression, hypotension, and bradycardia.
- EPIDEMIOLOGY: Exposure to amitraz is rare in the United States, but more common in other countries. Severe toxicity is uncommon, but deaths have been reported.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Most patients will have mild to moderate gastrointestinal symptoms and mild sedation. Miosis is common; mydriasis may also occur. Hypersalivation is also common.
- SEVERE TOXICITY: Severe toxicity may include bradycardia, hypotension, sedation, seizures, respiratory depression, and coma. Hyperglycemia, acidosis (both respiratory and metabolic) and mild elevation of serum transaminase activity have also been reported. Aspiration pneumonitis may develop from the solvent vehicle (commonly xylene). There is a single report describing torsade de pointes.
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