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ACUTE EXPOSURE INFORMATION
- USES: A skeletal muscle relaxant used for pain relief in acute musculoskeletal conditions.
- PHARMACOLOGY: Inhibition of alpha and gamma motor neurons via the brain stem.
- TOXICOLOGY: Displays anticholinergic, antihistaminergic, and CNS depressant effects in overdose. It is also a weak norepinephrine and serotonin reuptake inhibitor.
- EPIDEMIOLOGY: Poisoning is common but rarely severe.
- WITH THERAPEUTIC USE
- Sedation, flushing, dry mouth, and hallucinations.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE POISONING: Sedation, anticholinergic effects (ie, mydriasis, flushing, fever, dry mouth, decreased bowel sounds, hallucinations), sinus tachycardia, mild hypertension or hypotension, and nausea and vomiting are common after overdose.
- SEVERE POISONING: Severe effects may include significant hypotension, respiratory depression, and coma. Cyclobenzaprine is a cyclic amine with structural similarity to the tricyclic antidepressant amitriptyline. Therefore, theoretically, conduction delays and ventricular dysrhythmias are of concern but are exceedingly rare even in large overdoses.
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