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ACUTE EXPOSURE INFORMATION
- There are no reported cases of human toxicity due to valinomycin exposure. In isolated mouse and rabbit eye lenses, a 4-hour incubation in a valinomycin solution caused imbalances of the sodium-potassium gradient and cataract formation. Direct eye instillation or subconjunctival injection caused decreased intraocular pressure in rabbits and monkeys. Topical conjunctival application also caused corneal edema. Dermal absorption occurs.
- It has been speculated that valinomycin might cause toxicity to the central and peripheral nervous systems, heart, and kidneys as is seen with other ionophore antibiotics such as amphotericin B. However, no such effects were seen in some animal experiments.
- In other animal experiments, valinomycin has produced aggressive behavior, tremors, seizures, and peripheral nervous system effects. Tolerance develops to some of the behavioral effects. It has caused cardiotoxicity at high doses in experimental animals.
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