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ACUTE EXPOSURE INFORMATION
- Human overdose exposure data are limited. Nausea may occur following exposure to massive amounts. Its low vapor pressure makes inhalation toxicity unlikely. Picloram is not reported to be a sensitizer. The dust may be irritating to the eyes, skin, nose, throat and respiratory tract. Corneal injury is unlikely. Picloram has poor dermal absorption, but is rapidly absorbed from the gastrointestinal tract. It is cleared swiftly via the kidneys with >90% of the absorbed dose excreted unchanged in the urine. Systemic toxicity is thought to be low.
- Experimental animal exposures have produced skin rashes, hair loss, tachycardia, ataxia, diarrhea, leukopenia, vaginal bleeding, prostration, seizures, and liver and kidney lesions.
- IARC has classified picloram as not classifiable as to its carcinogenicity to humans (Group 3). Mutations have been observed in microorganisms. Developmental abnormalities have been noted in experimental animals.
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