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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Dose-limiting bone marrow suppression is the most frequent adverse effect. Patients with an inherited deficiency of thiopurine methyltransferase may develop rapid bone marrow suppression following the initiation of treatment. Additionally hepatotoxicity, hyperuricemia, nausea and vomiting, anorexia, and stomatitis have been reported following thioguanine administration.
- WITH POISONING/EXPOSURE
- There are no published reports of overdose at the time of this review. The manufacturer reports that signs and symptoms after overdose may be immediate, such as nausea and vomiting, malaise, hypertension, and diaphoresis, or delayed, such as myelosuppression and azotemia. Reversible myelosuppression has been reported following the ingestion of a single oral dose of thioguanine 35 mg/kg.
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