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Example Content from MEDITEXT for 141-43-5:


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ACUTE EXPOSURE INFORMATION

  1. USES: Ethanolamine is a sclerosing agent used primarily for the treatment of esophageal varices with recent bleeding. It also has widespread use in industry.
  1. PHARMACOLOGY: Ethanolamine and oleic acid trigger an inflammatory response resulting in fibrosis and possible occlusion of the vein both in intravascularly and extravascularly. Oleic acid also activates coagulation in vivo by releasing tissue factor and activation of Hageman factor (Factor XII), but the ethanolamine component does not inhibit fibrin clot formation by chelating calcium so that a procoagulant action has not been demonstrated.
  1. EPIDEMIOLOGY: Overdose is rare.
  1. WITH THERAPEUTIC USE
    1. ADVERSE EFFECTS: COMMON: Pleural effusion, esophageal ulcer, pyrexia, retrosternal pain, esophageal stricture. LESS COMMON: Esophagitis, tearing of the esophagus, sloughing of the mucosa overlying the injected varix, necrosis, periesophageal abscess and perforation. RARE: bacteremia, anaphylactic shock, acute renal failure and disseminated intravascular coagulation.
  1. WITH POISONING/EXPOSURE
    1. TOXICITY: Injection of too large a volume of ethanolamine can result in intramural necrosis of the esophagus with complications leading to death. It is a pulmonary, GI, skin and eye irritant.
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