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Example Content from MEDITEXT for 13410-01-0:


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ACUTE EXPOSURE INFORMATION

  1. Elemental selenium has a relatively low order of toxicity; selenium is an ESSENTIAL TRACE METAL, and CHRONIC DEFICIENCY can lead to fatal cardiomyopathies. Industrial workers exposed for up to 26 years had a normal death pattern. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption, although specific information on the possible dermal absorption of sodium selenate was not found.
  1. Chronic selenium poisoning resembles chronic arsenic poisoning. Nausea, vomiting, white streaks of the nails, pallor, upper respiratory irritation, paronychiae, hair loss, skin rashes, irritability, fatigue, hyperreflexia, EKG changes, a garlic odor on the breath, and a metallic taste in the mouth may be noted with chronic selenium exposure.
    1. Screening laboratory values such as complete blood counts and liver and renal function tests are usually within normal limits. Liver and renal lesions have been seen in experimental animals.
  1. Acute poisonings with selenium metal and its salts are rare. SELENITE toxicity may include facial flushing, a lightheaded sensation, and muscle tenderness and tremors.
    1. Inhalation of selenium dusts may cause headache, cough, nasal discharge, upper respiratory tract irritation, epistaxis, and olfactory fatigue. Transient dyspnea has been seen.
    1. Severe eye irritation may be seen with selenium dust exposure.
  1. While chronic occupational selenium exposure has not been reported to result in disabling disease, paralysis and hemiplegia were noted in an endemic outbreak of dietary hyperselenosis in China.
  1. Acute ingestion of 2000 mg of sodium selenate by an adolescent caused a garlic odor of the breath, diarrhea, EKG changes indicating possible anterolateral myocardial damage, elevated liver function tests, muscle aches and pains, and irritability.
  1. Anemia and marked hepatic necrosis, hemorrhage, and cirrhosis were found in experimental animals fed 5 to 15 ppm of selenium chronically in the diet. These effects have not been reported in exposed humans.
  1. Sodium selenate releases toxic and irritating fumes of selenium and sodium oxide when heated to decomposition.
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