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ACUTE EXPOSURE INFORMATION

  1. USES: Zinc phosphide (Zn3P2, ZnP) is an inorganic dark gray crystalline powder used as a rodenticide.
  1. TOXICOLOGY: Its toxicity is secondary to the release of phosphine gas on contact with moisture or moist air. Phosphine blocks cytochrome C oxidase. This document covers effects from ingestion of zinc phosphide. Information on the effects of inhalation of phosphine gas are covered in a separate management.
  1. EPIDEMIOLOGY: Human poisoning is uncommon, but occurs worldwide and can be fatal.
  1. WITH POISONING/EXPOSURE
    1. MILD TO MODERATE TOXICITY: Nausea, vomiting, and abdominal pain are common. Tachycardia, fatigue, headache, dizziness, anxiety, restlessness, dyspnea, tachypnea, and hypoglycemia may develop.
    1. SEVERE TOXICITY: CNS excitation or depression, hypotension, dysrhythmias, metabolic and respiratory acidosis, jaundice, elevated liver enzymes, seizures, and acute lung injury may develop. Pancreatitis is a rare complication.
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