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ACUTE EXPOSURE INFORMATION

  1. INHALATION (PRIMARY EXPOSURE/EFFECTS) -
    1. METAL FUME FEVER is a brief, self-limited illness characterized by fever, chills, myalgias, vomiting, and malaise which most commonly results from inhalation of freshly formed zinc oxide fume. Complete recovery generally occurs within 24 to 48 hours. Other metal oxides can cause metal fume fever and may be complicated by other serious health effects (e.g., cadmium).
    1. A few sources claim that finely divided zinc oxide dust can cause metal fume fever. Zinc oxide dust is generally considered a nuisance dust; adverse effects are unlikely when exposures are kept under reasonable control.
  1. ORAL EXPOSURE -
    1. Toxicity is low, based on animal studies. It has been speculated that severe oral exposure to airborne powders or dusts of zinc compounds, in general, may cause gastric upset and vomiting due to the swallowed dusts.
  1. CHRONIC EXPOSURE -
    1. It has been reported that working in environments with extremely high, uncontrolled concentrations of zinc oxide fumes or dust for more than 6 months may lead to development of dermatitis, boils, conjunctivitis and gastrointestinal disturbances. Exposures to other chemicals were likely in some reports.
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