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ACUTE EXPOSURE INFORMATION
- Pyrene is irritating to exposed skin and eyes. No other acute toxic effects in humans were mentioned in available literature at the time of this review. Exposed experimental animals have developed excitation and muscle spasticity. Pyrene is an experimental mutagen and an equivocal experimental animal tumorigen. However, the IARC has listed pyrene as having no evidence for animal carcinogenesis and it was negative or inconclusive in all EPA GENETOX Program (1986) assays.
- Some unspecified teratogenic effects were noted in workers. Human exposures to polyaromatic hydrocarbons in general are approximately 99 percent from dietary sources. Although there may be reasonably high concentrations of pyrene in foods, there is little data to indicate that any serious health effects occur from its ingestion in dietary sources.
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