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ACUTE EXPOSURE INFORMATION
- Human data on dimethylacetamide (DMAC) toxicity is limited. In human clinical trials, toxic effects of intravenous DMAC included dose-related gastrointestinal (vomiting) and central nervous system toxicity (CNS depression followed by mental excitation with delusions and hallucinations), and hypotension. Acute toxic dermal and inhalation exposure has resulted in severe hepatitis, rhabdomyolyses, hallucinations, and coagulopathy. Dermal irritation with burns has been reported following liquid exposure.
- In animal studies, target organs for toxicity are the liver, central nervous system, and skin. Liver damage appears to be produced most consistently in animal studies.
- Systemic effects in humans can occur through oral, dermal and inhalational absorption.
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