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ACUTE EXPOSURE INFORMATION
- USES: Tranexamic acid is indicated for the short-term use (2 to 8 days) to reduce or prevent hemorrhage and to reduce the need for replacement therapy during and following tooth extraction in hemophiliac patients.
- PHARMACOLOGY: Tranexamic acid is a synthetic amino acid analogue that interferes with the activation of plasminogen to plasmin. This produces an antifibrinolytic effect preventing clot breakdown reducing the risk of bleeding.
- EPIDEMIOLOGY: Overdoses are rare. Several cases of unintentional administration of tranexamic acid have been reported.
- WITH THERAPEUTIC USE
- ADVERSE EFFECTS: COMMON: Nausea, vomiting, and diarrhea are common occurrences with tranexamic acid therapy. INFREQUENT: Adverse effects that may occur less frequently following therapeutic administration of tranexamic acid include thromboembolism, myocardial infarction, renal cortical necrosis, visual disturbances, headaches and giddiness.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Tranexamic overdose data are limited. Nausea, vomiting, orthostatic hypotension may occur in the event of an overdose.
- SEVERE TOXICITY: The major adverse events due to tranexamic acid are the potential thromboembolic events, such as myocardial infarctions, deep vein thrombosis, and pulmonary embolism. Severe pain, seizures, myoclonic twitching of facial muscles, ventricular fibrillation, coma, and death have been reported in patients following unintentional intrathecal administration of tranexamic acid.
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