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• [Effects of endosulfan on reproductive system of male pups after gestational and lactational exposure]
• [Effects of endosulfan on the spermatogenesis and oxidative damage in rats]
• [Estimating Permissible Intake Level for Endosulfan Using Benchmark Dose Based on Reproductive Toxicity]
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Example Content from MEDITEXT for 115-29-7:


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ACUTE EXPOSURE INFORMATION

  1. USES: Endosulfan is a chlorinated hydrocarbon insecticide. This agent is in a phase-out process to end its use within the United States, with a complete ban by 2016.
  1. PHARMACOLOGY: These insecticides are neurotoxic to insects.
  1. TOXICOLOGY: Chlorinated hydrocarbon insecticides are likely to primarily act as "axon poisons", interfering with movement of ions across membranes resulting in CNS excitation and repetitive neuronal firing. Some of the agents are GABA antagonists as well. They may also sensitize myocardial tissue to catecholamines and predispose one to dysrhythmias in a similar manner as chlorinated hydrocarbon solvents.
  1. EPIDEMIOLOGY: Rare exposure. While inadvertent exposures are rarely toxic, large or deliberate exposures have resulted in significant morbidity and death.
  1. WITH POISONING/EXPOSURE
    1. The following are symptoms from chlorinated hydrocarbon insecticides in general. All of these effects may not be documented for endosulfan, but could potentially occur in individual cases.
    1. MILD TO MODERATE TOXICITY: Nausea, vomiting, abdominal pain, tremor, paresthesias, headache, and dizziness.
    1. SEVERE TOXICITY: Seizures (may progress to status epilepticus), myoclonus, agitation, ataxia, confusion, hypotension, dysrhythmias, respiratory failure, metabolic acidosis, and coma. Elevated liver enzymes, renal failure, and thrombocytopenia are rare effects.
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