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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Capillary leak syndrome usually develops within a few hours of the start of aldesleukin (IL-2) therapy and begins to resolve within a few hours of its discontinuation. Common manifestations include hypotension, tachycardia and oliguria. Generalized edema, weight gain, pleural effusions, pulmonary edema, ascites, renal insufficiency and confusion may also develop.
- Nausea, vomiting and diarrhea develop in most patients and diarrhea may be severe. Anemia, leukopenia and thrombocytopenia may develop but are rarely severe. Fever and chills are also common during therapy.
- Increased serum bilirubin is common, increased aminotransferase levels develop less often and both usually resolve after therapy is discontinued. Electrolyte disturbances (hypomagnesemia, hypocalcemia, hypokalemia, and hypophosphatemia) develop in about 10% of patients but are rarely severe.
- WITH POISONING/EXPOSURE
- Overdose information is limited. Exceeding the recommended dose has ben associated with a more rapid onset of typical adverse effects.
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