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ACUTE EXPOSURE INFORMATION
- Caprolactam exposure causes eye, skin, and mucous membrane irritation and skin sensitization. Respiratory tract irritation and coughing may occur after inhalation exposure. Respiratory sensitization with bronchospasm was demonstrated in one group of occupationally exposed workers.
- One worker developed dermatitis, seizures, fever, and leukocytosis after caprolactam exposure. Caprolactam is rarely a convulsant.
- Direct contact with the hot liquid can cause burns of the eyes and skin. Prolonged skin contact can cause dermal burns, especially if the liquid is spilled into footwear.
- Contact dermatitis and eczema have been noted in chronically exposed workers. Hypersensitivity dermal reactions may occur. Skin that is severely affected may peel, but seldom blisters. The nails may become brittle.
- A group of workers exposed to caprolactam, cyclohexanone, and dinil had an increased incidence of dyspermia. Complications of pregnancy, oligodysmenorrhea, and hypermenorrhea have been noted.
- Seizures and liver and kidney injuries developed in experimental animals, with respiratory stimulation and mild hypotension resulting from large oral doses. No evidence of carcinogenicity was found in experimental animals.
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